We are a research group exploring the intersection of epitranscriptomics, telomere biology, and cancer to uncover new therapeutic opportunities. Our work focuses on RNA modifications, telomere maintenance mechanisms, and oncogenic transcriptional programs, with a particular emphasis on pediatric cancer neuroblastoma.
Epitranscriptomics & Cancer – We investigate how RNA modifications such as m6A influence gene expression, genome stability, and tumor progression, particularly in MYCN-driven neuroblastoma and ALT-positive cancers.
Using inhouse developed MYCN neuroblastoma model, We try to unravel the role of the MYCN oncogene in the early transformation of human trunk neural crest cells (tNCC).
Telomere Biology & Alternative Lengthening of Telomeres (ALT) – Our studies explore how non-coding RNAs and chromatin dynamics regulate telomere maintenance, a critical mechanism in aggressive cancers.
Viral Epitranscriptomics – We examine how RNA modifications impact viral infections, including the regulation of SARS-CoV-2 replication and host response.
Our Approach
We utilize a combination of stem cell models, functional genomics, high-throughput sequencing, and molecular biology techniques to decode the complex regulatory networks governing cancer and viral infections.
By bridging epitranscriptomics with disease biology, our goal is to identify novel therapeutic targets that can improve treatment strategies for cancer and infectious diseases.
Tanmoy Mondal Lab 